Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours
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منابع مشابه
Chemopreventive effect of celecoxib and expression of cyclooxygenase-2, Casapase-3 and AGNOR on chemically- induced rat submandibular salivary gland neoplasm
BACKGROUND: Cyclooxygenase-2 (COX)-2 inhibitor (Celecoxib) is a non-steroidal antiinflammatory drug (NSAIDs) and over-expression of COX-2 protein and mRNA has been reported in various cancer tissues. Therefore, it has been suggested that COX-2 is related to carcinogenesis. METHODS: Twenty five albino rats were used .They were divided into 3 groups; group I (normal control) and group II and III ...
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Objective(s): Noise-induced hearing loss (NIHL) is the major cause of acquired hearing loss. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is a non- steroidal anti- inflammatory drug (NSAID) with known antioxidant and antineoplastic activity. Therefore, we monitored the extent of temporary noise- induced threshold shifts (TTS) and cochlear damage caused by high level 4- kHz noise exposure t...
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15 صفحه اولGastric Adenomas of Trefoil Factor 1-deficient Mice Cyclooxygenase-2 Expression and Effect of Celecoxib in
Expression of cyclooxygenase-2 (Cox-2) is elevated in gastric adenocarcinomas and precursor lesions leading to this disease. Mice deficient for trefoil factor 1 (TFF1) develop a pyloric adenoma with full penetrance. Because inhibition of Cox-2 suppresses tumor growth in several animal models, we studied expression of Cox-2 and effect of a selective Cox-2 inhibitor celecoxib in gastrointestinal ...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2002
ISSN: 0959-9673
DOI: 10.1046/j.1365-2613.2002.00228.x